Schedule

The EBV/KSHV Meeting will take place in the Memorial Union on the University of Wisconsin-Madison campus.

*Tentative Agenda – Details Subject to Change*

July 28

Saturday

 
9:00 AM – 5:00 PM Satellite Meeting on EBV hydroa vacciniforme

Organized by: Jeffrey Cohen

Old Madison
12:00 PM – 7:00 PM Registration Annex
5:40 PM – 6:00 PM Welcome & Henle Lecture Introduction Shannon Hall
6:00 PM Keynote Address 1 (Henle Lecture)

Paul Lieberman

Shannon Hall
7:00 PM Dinner Reception Tripp Commons

 

July 29

Sunday

 
8:00 AM – 5:00 PM Registration Annex Room
8:00 AM Coffee Shannon Hall Lobby
8:45 AM Welcome & Conference Logistics Shannon Hall
Session 1

9:00 AM – 10:30 AM

Gene Expression/Epigenetics

Session Chairs: Ke Lan & Wolfgang Hammerschmidt

Shannon Hall
9:00 AM Global Changes in the Host B cell During the Pre-latent Phase of EBV Infection

 

Paulina Mrozek-Gorska

 

9:15 AM Single-Cell Analysis of Gammaherpesvirus Infection and Gene Expression

 

Lauren Oko

 

9:30 AM 3D architecture of host-pathogen genomic interactions during EBV reactivation

 

JJ Miranda

 

9:45 AM Modulation of Cellular CpG DNA Methylation by Kaposi’s Sarcoma Associated Herpesvirus

 

Guy Journo

 

10:00 AM Epstein-Barr Virus Nuclear Antigen EBNA-LP is Essential for Transforming Naive B Cells, and Supports the Activation of Viral Genes, but not EBNA2-Induced Cellular genes

 

Rob E. White

 

10:15 AM Polycomb Recruitment During Latency Establishment: A Comparative Study

 

Thomas Günther

 

10:30 AM – 11:00 AM Break Shannon Hall Lobby

Concurrent Sessions

Session 2A

11:00 AM – 12:30 PM

Immunity & Immune Therapy

Session Chairs: Dirk Dittmer & Rajiv Khanna

Shannon Hall
11:00 AM A Role for EBNA2 in Mechanisms that Foster Some Autoimmune Diseases

 

John B. Harley

 

11:15 AM Disruption of IL-15 Signaling and NK cells Facilitates Oncogenesis of Gammaherpesviruses in SIV-Infected Rhesus Macaques

 

Yoshinori Fukazawa

 

11:30 AM Dramatically Decreased and Delayed CD8 T-Cell Responses during Asymptomatic EBV Seroconversion

 

Liisa K. Selin

 

11:45 AM Gammaherpesvirus Infected B Cells Display Abnormal Repertoire

 

Monika Zelazowska

 

12:00 PM Defective EBV Particles equipped with Latent Epitopes offer Increased Protection Against EBV Infection

 

Dwain van Zyl

 

12:15 PM Candidate Public T-Cell Responses to Kaposi sarcoma Identified through T-Cell Receptor Sequencing of Tumor Infiltrating Lymphocytes

 

Warren Phipps

 

Session 2B

11:00 AM – 12:30 PM

Therapeutics & Vaccines

Session Chairs: Robert Yarchoan & Mu-sheng Zeng

Play Circle
11:00 AM Toward the Clinical Development of an EBNA1 Inhibitor for the Treatment of EBV-Associated Nasopharyngeal Carcinoma

 

Troy E. Messick

 

11:15 AM The Unique Structure of the LMP1 – TRAF6 Complex is Critical for Viral Cell Transformation and Serves as Target for Inhibitory Molecules

 

Arnd Kieser

 

11:30 AM CRISPR Resistance Screens Reveal Genetic Mediators of Immunomodulatory Drugs in Primary Effusion Lymphoma

 

Ajinkya Patil

 

11:45 AM Dual Role in Fighting Viral Malignancies: Next Generation Epigenetic Modifier for Viral Gene Activation and Anti-Tumor Immune Response

 

Robert A. Baiocchi

 

12:00 PM Modulating IL-7 Cytokine Receptor Signaling to Enhance the Persistence and Anti-Tumor Efficacy of Epstein-Barr Virus (EBV) Specific T-Cells in EBV Positive Malignancies

 

Sandhya Sharma

 

12:15 PM Spironolactone Blocks EBV Production by Degrading XBP Protein, A Cellular Transcription Factor that Acts as a Cofactor for EBV SM Function

 

Dinesh Verma

 

12:30 PM – 2:00 PM Lunch Great Hall
Session 3

2:00 PM – 4:00 PM

Virus Host Interactions I

Session Chairs: Mandy Muller & Ben Gewurz

Shannon Halll
2:00 PM A Genome-wide Screen of EBV Proteins that Modulate Host SUMOylation Identifies a SUMO E3 Ligase conserved in Herpesviruses

 

Lori Frappier

 

2:15 PM Computational Analysis of Ribonomics Datasets Identifies Long non-coding RNA targets of γ-herpesviral miRNAs

 

Rolf Renne

 

2:30 PM The Receptor or Coreceptors in Epstein-Barr Virus Infection of Nasopharyngeal Epithelial Cells

 

Mu-sheng Zeng

 

2:45 PM Examination of the Effects of Rhesus Macaque Rhadinovirus (RRV) Infection and Viral CD200 (vCD200) on Cellular Gene Expression Profiles During in vivo Infection

 

Ryan D. Estep

 

3:00 PM PIAS1 restricts Epstein-Barr Virus Reactivation and it is Antagonized by Caspases Upon Lytic Induction

 

Renfeng Li

 

3:15 PM Metabolic Reprogramming of Kaposi’s Sarcoma Associated Herpes Virus Infected B-cells in Hypoxia

 

Rajinish K. Singh

 

3:30 PM Caspase 3 Activation Facilitates Lytic Replication of Epstein-Barr Virus in Epithelial Cells

 

Dong-Yan Jin

 

3:45 PM EBNA3A Regulates Apoptosis at Early and Late Times After Infection in Epstein Barr Virus-Infected B Cells

 

Joanne Dai

 

4:00 PM – 4:30 PM Break Shannon Hall Lobby
4:30 PM Keynote Address II

Blossom Damania

Shannon Hall
5:30 PM – 7:00 PM Dinner Great Hall
7:00 PM – 9:00 PM Poster Session I – Wine/Dessert Tripp Commons & Main Lounge

 

July 30

Monday

 
7:30 AM- 3:00 PM Registration Annex Room
7:30 AM Coffee Shannon Hall Lobby
Session 4

8:00 AM – 10:00 AM

Lytic Cycle I

Session Chairs: Fanxiu Zhu & Richard Longnecker

Shannon Hall
8:00 AM The EBV Glycoprotein BDLF2 is Essential for the Infection of Stratified Epithelium

 

Ian Hayman

 

8:15 AM Kaposi Sarcoma-Associated Herpesvirus gH Is Essential for Viral Infection, but Not for Virion Assembly or Egress from Cells and is an Ideal Target for Vaccine Development

 

Javier G. Ogembo

 

8:30 AM An Early Lytic Gene Regulates Immediate Early Gene BZLF1

 

Xiaofan Li

 

8:45 AM Immune Mechanisms of Protection Against Latency from Vaccination of a Genetically Engineered Gamma-Herpesvirus

 

Ting-Ting Wu

 

9:00 AM How is EBV’s Genome Amplified during its Lytic Cycle?

 

Thejaswi Nagaraju

 

9:15 AM The Kaposi’s Sarcoma Herpesvirus Non-Structural Membrane Protein pK15 Recruits the Class II PI3K Phosphatidylinositol 4-phosphate 3-kinase C2 alpha to Activate Productive Viral Replication

 

Bizunesh Abere Alamirew

 

9:30 AM CAGE-seq Analysis of Epstein-Barr Virus Lytic Gene Transcription: 3 Kinetic Classes from 2 Mechanisms

 

Reza Djavadian

 

9:45 AM Phosphorylation Regulates the Function of the Epstein-Barr virus Pre-Initiation Complex in Transcription of Late Genes

 

Ayman S. El-Guindy

 

10:00 AM – 10:30 AM Break Shannon Hall Lobby

Concurrent Sessions

Session 5A

10:30 AM – 12:00 PM

Gene Expression II

Session Chairs: Kenneth Kaye & Lori Frappier

Shannon Hall
10:30 AM Multiple Roles for EBV microRNAs in Regulating EBV Reactivation

 

Rebecca Skalsky

 

10:45 AM KSHV vIL-6 Intercellular Signaling Increases Integrin Beta 3 Levels and is Dependent on Activated STAT3

 

Ricardo Rivera-Soto

 

11:00 AM Epstein-Barr Virus Nuclear Antigen Leader Protein Co-Activates EP300

 

Chong Wang

 

11:15 AM Epstein Barr Virus (EBV) Latency Gene Expression in Solid Organ (SOT) and Bone Marrow (BMT) Post-transplant Lymphoproliferative Disorders (PTLDs)

 

Amy Chadburn

 

11:30 AM CRISPR-Cas9 Mediated Knockout of Viral ORF57 Gene from All Copies of the KSHV Genome in BCBL-1 Cells

 

Zhi-Ming Zheng

 

11:45 AM The Epstein-Barr Virus BHLF1 Locus Contributes to Viral Latency and B cell Immortalization

 

Lena Lupey-Green

 

Session 5B

10:30 AM – 12:00 PM

Epidemiology

Session Chairs: Charles Wood & Alan Chiang

Play Circle
10:30 AM Newly Derived endemic Burkitt Lymphoma Cell Lines from Kenyan Patients and the Makings of an Avatar Mouse Model

 

Ann M. Moormann

 

10:45 AM Potential Correlates of Mother to Child Transmission in the Humoral Response to KSHV in Zambia

 

Lisa K. Poppe

 

11:00 AM Genomic Analyses Support the Association of Pathogenic Variants of Epstein-Barr Virus with Nasopharyngeal Carcinoma

 

Alan K.S. Chiang

 

11:15 AM Genome Sequencing Analysis Identifies Epstein-Barr Virus Subtypes Associated with the Risk of Nasopharyngeal Carcinoma

 

Miao Xu

 

11:30 AM The Zp-V3 Variant of the Epstein-Barr Virus BZLF1 Promoter Enhances Lytic Reactivation in Response to B-cell Receptor Stimulation and is Over-represented in Burkitt Lymphomas

 

Jillian A. Bristol

 

11:45 AM Epstein-Barr Virus (EBV) Serological Profile and Hodgkin Lymphoma (HL) Risk

 

Zhiwei Liu

 

12:00 PM – 1:00 PM Lunch Great Hall
1:00 PM Keynote Address II

Bettina Kempkes

Shannon Hall
Session 6

2:00 PM – 3:00 PM

Co-Infections

Session Chairs: Denise Whitby & Christian Münz

Shannon Hall
2:00 PM Malaria as a Risk Factor for Early Age of KSHV Infection in a Cohort of Children in Western Kenya

 

Rosemary Rochford

 

2:15 PM KSHV Requires EBV for Infection of Peripheral B Cells

 

Aurélia Faure

 

2:30 PM Tumor Epstein-Barr Virus Status is Prognostic in Primary Effusion Lymphoma

 

Kathryn Lurain

 

2:45 PM Epstein-Barr virus (EBV) Enhances Latent Plasmid Maintenance of Kaposi Sarcoma-associated Herpesvirus (KSHV)

 

Dirk Dittmer

 

3:00 PM – 8:00 PM Optional Excursion + Dinner on Own
8:00 PM – 10:00 PM Poster Session II – Beer/Chese Tripp Commons & Main Lounge

 

July 31

Tuesday

 
7:30 AM – 5:30 PM Registration Annex Room
7:30 AM Coffee Shannon Hall Lobby
Session 7

8:00 AM – 10:00 AM

Non-Coding RNAs

Session Chairs: Scott Tibbetts & Erik Flemington

Shannon Hall
8:00 AM Misprocessing of Cellular Noncoding RNAs as a Pathway for Cell-Intrinsic Immune Activation

 

John Karijolich

 

8:15 AM Identifying EBV microRNA Targets in B-cell Lymphoma and Gastric Cancer Using CLASH

 

Nathan Ungerleider

 

8:30 AM Transcriptional Regulation of Viral ncRNAs

 

Ashley N. Knox

 

8:45 AM EBV Encoded miR-BART10-3p and miR-BART22 Promote Invasion and Metastasis by Activating Canonical Wnt/β-catenin Signaling Pathway in EBV-Associated Gastric Carcinoma

 

Chun-kui Shao

 

9:00 AM A Herpesvirus Utilizes a Sm-class Non-coding RNAs as a miRNA Adaptor to Modulate Host Gene Expression

 

Demian Cazalla

 

9:15 AM Impact of Demethylating Agents on Nasopharyngeal Carcinoma Xenografts: de novo Expression of Cp/Wp Transcripts and BHRF1 microRNAs

 

Pierre Busson

 

9:30 AM The Secondary Structure of the MHV68 Noncoding RNA TMER4 is Essential for Function at a Critical in vivo Dissemination Bottleneck

 

Brett A. Hoffman

 

9:45 AM Epstein Barr virus circRNAome

 

Erik Flemington

 

10:00 AM-10:30 AM Break Shannon Hall Lobby

Concurrent Sessions

Session 8A

10:30 AM – 12:00 PM

Latency

Session Chairs: Jennifer Totonchy & Maria Masucci

Shannon Hall
10:30 AM EBV Persistence without its EBNA3A and 3C Oncogenes in vivo

 

Anita Murer

 

10:45 AM G-quadruplexes Regulate mRNA Translation of LANA to Control Antigen Presentation during Latency

 

Prerna Dabral

 

11:00 AM LMP2A Regulates BART miRNAs Transcription by Translational Activation of ETS Family Genes

 

Hyoji Kim

 

11:15 AM EBV Latency IIb is Phenotypically Distinct from Latency III Independent of LMP1 Expression

 

Joshua E. Messinger

 

11:30 AM Uracil DNA Glycosylase of Gammaherpesvirus and Mammals Differentially Support Mutational Outcomes

 

Kevin McBride

 

11:45 AM Successful Short Term Infection of Humanized Mice with EBV Lacking EBNA3 Genes Contrasts Their Essential Role in B Cell Transformation In Vitro and Their Role in Favouring Latency in Memory B Cells

 

Christine T. Styles

 

12:00 PM Enhancement of in vivo Latency by Substitution of the KSHV LANA DNA Binding Domain with that of MHV68 in Chimeric Virus

 

Kenneth M. Kaye

 

12:15 PM Identification of ARKL1 as a Jun-interacting Factor that Negatively Regulates EBV Reactivation

 

Umama Zia Siddiqi

 

Session 8B

10:30 AM – 12:00 PM

Virus-Host Interactions II

Session Chairs: Britt Glaunsinger & Yasuaki Harabuchi

Play Circle
10:30 AM Role of KSHV in T cell Infiltration in Kaposi’s Sarcoma Microenvironment

 

Yan Yuan

 

10:45 AM Epstein-Barr virus LMP1 Hijacks the Host ESCRT Machinery for Exosomal Secretion

 

Dingani Nkosi

 

11:00 AM vIRF-1 Regulates Mitochondrial Content by Promoting Mitophagy during HHV-8 Replication

 

Mai Tram Vo

 

11:15 AM Epstein-Barr Virus Activates F-box Protein FBXO2 to Limit Viral Infectivity by Targeting Glycoprotein B for Degradation

 

Lin Feng

 

11:30 AM Cell-Mediated Immune Responses to Persistent KSHV Infection in Mice with Reconstituted Human Immune System Components

 

Nicole Caduff

 

11:45 AM Epstein-Barr Virus Infection Promotes Epithelial Cell Growth by Attenuating Differentiation-Dependent Exit from Cell Cycle

 

Mark R. Eichelberg

 

12:00 PM IFN-ƴ Responses in Peripheral Blood Lymphocytes of Patients with KSHV-associated Diseases Treated with Pomalidomide and Liposomal Doxorubicin

 

Kathryn Lurain

 

12:15 PM Epstein-Barr Virus-Infected Tonsillar Marginal Zone B Cells in vivo as a Precursor for Immunosuppression-Related B-cell Lymphoma

 

Charles Torgbor

 

12:30 PM – 1:00 PM General EBV Association Meeting Shannon Hall
12:30 PM – 1:30 PM Lunch Great Hall
Session 9

1:30 PM – 3:00 PM

Transformation

Session Chairs: Thomas Schulz & Micah Luftig

Shannon Hall
1:30 PM Increased Association Between EBV EBNA2 From Type 2 Strains And The Transcriptional Repressor BS69 Restricts B Cell Growth

 

Michelle J. West

 

1:45 PM The Oncogenic Kaposi’s Sarcoma-Associated Herpesvirus Encodes a Mimic of the Tumor Suppressor miR-16

 

Kylee Morrison

 

2:00 PM Role of mTOR Complexes in the Maintenance of Nasopharyngeal Carcinoma Cancer Stem Cells

 

Nannan Zhu

 

2:15 PM An Essential Role of Urea Cycle and Argininosuccinate Synthase 1 in KSHV-induced Cellular Transformation

 

Tingting Li

 

2:30 PM Reverse Engineering EBV Driven B Cell Transformation and Lymphomagenesis in the Mouse

 

Thomas Sommermann

 

2:45 Pm An EBNA3C-deleted Epstein-Barr virus (EBV) Mutant Causes B-cell Lymphomas with Delayed onset in a Cord Blood-Humanized Mouse Model

 

James Romero-Masters

 

3:00 PM – 3:30 PM Break Shannon Hall Lobby

Concurrent Sessions

Session 10A

3:30 PM – 5:00 PM

Lytic Cycle II

Session Chairs: Linda van Dyk & Mei-Ru Chen

Shannon Hall
3:30 PM Continuous DNA Replication Is Required For Late Gene Transcription And Maintenance Of Replication Compartments In Gammaherpesviruses

 

Dajiang Li

 

3:45 PM Intracellular Iron Chelation by a Novel Compound, C7, Induces Lytic Cycle of Epstein-Barr virus (EBV) in EBV-Positive Epithelial Malignancies

 

P.T. Stephanie Yiu

 

4:00 PM Application of the Air Liquid Interface Culture Method to Study EBV Pathogenesis in Polarized Airway Epithelia

 

Kathy Shair

 

4:15 PM NLRX1 Negatively Modulates Type I IFN to Facilitate KSHV Reactivation from Latency

 

Zhe Ma

 

4:30 PM BGLF2 Increases Infectivity of Epstein-Barr virus by Activating AP-1 upon de novo Infection

 

Takayuki Murata

 

4:45 PM The M81 Epstein-Barr virus associated RNA 2 enhances CXCL8 Production and Spontaneous Virus Lytic Replication in Primary B Lymphocytes

 

Zhe Li

 

Session 10B

3:30 PM – 5:00 PM

Virus-Host Interactions II

Session Chairs: Hongyu Deng & Cliona Rooney

Play Circle
3:30 PM The KSHV Protein ORF68 is a Proteasome-Manipulating Nuclease Required for DNA Packaging

 

Matthew Gardner

 

3:45 PM Epstein-Barr Virus Nuclear Antigen-1, Action and Reaction as an Oncogene

 

Joanna Wilson

 

4:00 PM Genome-wide Identification of Direct RTA Targets Reveals Key Host Factors for KSHV Lytic Reactivation

 

Bernadett Papp

 

4:15 PM EBV Lytic Replication in mTOR-Inhibited Epithelial Cells is Correlated with YY1 and Mnk1/2 Activities

 

Amy L. Adamson

 

4:30 PM Interferon-Stimulated Gene Product RNF213 Modulates KSHV Lytic Replication and Latency via Targeting RTA

 

Hongyu Deng

 

4:45 PM An Analog Sensitive Derivative of the Epstein Barr Virus v-Cdk Permits the Direct Identification of Substrates Participating in Multiple Stages of Gene Expression

 

Robert F. Kalejta

 

5:00 PM – 7:00 PM Joint Reception of EBV & KSHV Meeting with DNA Tumor Viruses Meeting Great Hall
7:00 PM Keynote Address IV

Douglas Lowy

Shannon Hall

 

August 1

Wednesday

 
8:00 AM – 5:00 PM Registration Annex Room
8:00 AM Coffee Shannon Hall Lobby
Session Topic

9:00 AM – 10:30 AM

Joint Session #1

Session Chairs: Erle Robertson & Elizabeth White

Shannon Hall
9:00 AM Point-of-Care Detection of KSHV and EBV to diagnose Kaposi sarcoma and endemic Burkitt lymphoma

 

Ethel Cesarman

 

9:30 AM The Chemokine CXCL14 Suppresses HPV-positive Head and Neck Cancer through the Antigen-Specific CD8+ T Cell Response

 

Dohun Pyeon

 

9:45 AM Development of a Humanized Mouse Model to Dissect the Role of T-cells in Epstein-Barr Virus Type 2 Latency and Lymphomagenesis

 

Carrie Coleman

 

10:00 AM Repair of E6/E7 induced Breaks in Viral Genomes Leads to Amplification

 

Laimonis Laimins

 

10:15 AM EBV gH/gL nanoparticle vaccines elicit antibodies that potently inhibit EBV glycoprotein-mediated B cell and epithelial cell membrane fusion and neutralize virus infection

 

Jeffrey Cohen

 

10:30 AM Break Shannon Hall Lobby
Session Topic

11:00 AM – 12:30 PM

Joint Session #2

Session Chairs: Jeffrey Cohen & Miranda Thomas

Shannon Hall
11:00 AM Local Dysregulation of the Immune Response Impairs Immunotherapy for HPV Associated Premalignancy

 

Ian Frazer

 

11:30 AM A Novel Virus Counteraction Mechanism against APOBEC3-Mediated Hypermutation and Restriction

 

Adam Cheng

 

11:45 AM Apobec3A is a Novel Restriction Factor Antagonizing Efficient HAdV Replication

 

Julia Mai

 

12:00 PM The Enzymatic Activities of the Viral dUTPase and Viral uracil-DNA Glycosylase Stabilize the Gammaherpesvirus Genome and Promote Pathogenesis in the Host

 

Laurie Krug

 

12:15 PM Epstein-Barr Virus Deubiquitinase BPLF1 Targets the RIG-I Signalosome to Inhibit the IFN Response

 

Maria G. Masucci

 

12:30 PM – 2:00 PM Lunch Great Hall
Session Topic

2:00 PM – 3:30 PM

Joint Session #3

Session Chairs: Michelle West & Doug Lowy

Shannon Hall
2:00 PM EBV-Induced Metabolic Dependency Factors in B-cell Transformation

 

Ben Gewurz

 

2:30 PM Identifying Genome-Wide Targets of the Late Gene Transcription Complex in KSHV

 

Divya Nandakumar

 

2:45 PM High Risk a-HPV Oncogenes Induce and Disrupt Tranlesion Synthesis

 

Sebastian Wendel

 

3:00 PM High Risk HPV Oncogenes Impair the Fanconi Anemia DNA Repair Pathway

 

Sujita Khanal

 

3:15 PM Structure-Guided Identification of Interaction Hotspot for Developing Inhibitors Interrupting KSHV Capsid Assembly

 

Danyang Gong

 

3:30 PM Break Shannon Hall Lobby
Session Topic

4:00 PM – 5:30 PM

Joint Session #4

Session Chairs: Laurie Krug & Bettie Steinberg

Shannon Hall
4:00 PM Discovery and characterization of human γ-Herpesvirus-circular RNAs

 

Tuna Toptan

 

4:15 PM Human and Viral Circular RNAs during Infection

 

Takanobu Tagawa

 

4:30 PM High-Risk HPV E7 Proteins Degrade the Tumor Suppressor PTPN14 to Limit Keratinocyte Differentiation

 

Elizabeth White

 

4:45 PM Human Papillomavirus E7 Oncoprotein Promotes the Epstein-Barr Virus Lytic Life Cycle in Immortalized Oral Keratinocytes

 

Kathleen Makielski

 

5:00 PM Inhibition of Epstein-Barr Virus Replication in Human Papillomavirus-Immortalized Keratinocytes

 

Joseph Guidry

 

5:15 PM EBV Hijacks PARP1 Activity to Control Both the Viral and Cellular Epigenome

 

Italo Tempera

 

6:00 PM – 11:00 PM Closing Banquet Great Hall

Key Note Speakers

Blossom Damania, Ph.D.
University of North Carolina Chapel Hill 

Bettina Kempkes, Prof. Dr.
Helmholtz Center Munich

Paul M. Lieberman, Ph.D.
The Wistar Institute

Doug Lowy, M.D.
Center for Cancer Research 
National Cancer Institute