The EBV/KSHV Meeting will take place in the Memorial Union on the University of Wisconsin-Madison campus.

*Tentative Agenda – Details Subject to Change*

Saturday, July 28th

9:00 AM – 5:00 PM Satellite Meeting on EBV hydroa vacciniforme

Organized by: Jeffrey Cohen

Old Madison
12:00 PM – 7:00 PM Registration Annex
5:40 PM – 6:00 PM Welcome & Henle Lecture Introduction Shannon Hall
6:00 PM Keynote Address I (Henle Lecture)

Paul Lieberman

Shannon Hall
7:00 PM Dinner Reception Tripp Commons

Sunday, July 29th

8:00 AM – 5:00 PM Registration Annex Room
8:00 AM Coffee Shannon Hall Lobby
8:45 AM Welcome & Conference Logistics Shannon Hall
Session 1

9:00 AM – 10:30 AM

Gene Expression/Epigenetics

Session Chairs: Ke Lan & Wolfgang Hammerschmidt

Shannon Hall
9:00 AM Global Changes in the Host B cell During the Pre-latent Phase of EBV Infection


Paulina Mrozek-Gorska


9:15 AM Single-Cell Analysis of Gammaherpesvirus Infection and Gene Expression


Lauren Oko


9:30 AM 3D architecture of host-pathogen genomic interactions during EBV reactivation


JJ Miranda


9:45 AM Modulation of Cellular CpG DNA Methylation by Kaposi’s Sarcoma Associated Herpesvirus


Guy Journo


10:00 AM Epstein-Barr Virus Nuclear Antigen EBNA-LP is Essential for Transforming Naive B Cells, and Supports the Activation of Viral Genes, but not EBNA2-Induced Cellular genes


Rob E. White


10:15 AM Polycomb Recruitment During Latency Establishment: A Comparative Study


Adam Grundhoff


10:30 AM – 11:00 AM Break Shannon Hall Lobby

Concurrent Sessions

Session 2A

11:00 AM – 12:30 PM

Lytic Cycle I

Session Chairs: Linda van Dyk & Mei-Ru Chen

Shannon Hall
11:00 AM Continuous DNA Replication Is Required For Late Gene Transcription And Maintenance Of Replication Compartments In Gammaherpesviruses


Dajiang Li


11:15 AM Intracellular Iron Chelation by a Novel Compound, C7, Induces Lytic Cycle of Epstein-Barr virus (EBV) in EBV-Positive Epithelial Malignancies


P.T. Stephanie Yiu


11:30 AM Application of the Air Liquid Interface Culture Method to Study EBV Pathogenesis in Polarized Airway Epithelia


Kathy Shair


11:45 AM NLRX1 Negatively Modulates Type I IFN to Facilitate KSHV Reactivation from Latency


Zhe Ma


12:00 PM BGLF2 Increases Infectivity of Epstein-Barr virus by Activating AP-1 upon de novo Infection


Takayuki Murata


12:15 PM The M81 Epstein-Barr virus associated RNA 2 enhances CXCL8 Production and Spontaneous Virus Lytic Replication in Primary B Lymphocytes


Zhe Li


Session 2B

11:00 AM – 12:30 PM

Therapeutics & Vaccines

Session Chairs: Robert Yarchoan & Mu-sheng Zeng

Play Circle
11:00 AM Toward the Clinical Development of an EBNA1 Inhibitor for the Treatment of EBV-Associated Nasopharyngeal Carcinoma


Troy E. Messick


11:15 AM The Unique Structure of the LMP1 – TRAF6 Complex is Critical for Viral Cell Transformation and Serves as Target for Inhibitory Molecules


Arnd Kieser


11:30 AM CRISPR Resistance Screens Reveal Genetic Mediators of Immunomodulatory Drugs in Primary Effusion Lymphoma


Ajinkya Patil


11:45 AM Dual Role in Fighting Viral Malignancies: Next Generation Epigenetic Modifier for Viral Gene Activation and Anti-Tumor Immune Response


Robert A. Baiocchi


12:00 PM Modulating IL-7 Cytokine Receptor Signaling to Enhance the Persistence and Anti-Tumor Efficacy of Epstein-Barr Virus (EBV) Specific T-Cells in EBV Positive Malignancies


Sandhya Sharma


12:15 PM Spironolactone Blocks EBV Production by Degrading XBP Protein, A Cellular Transcription Factor that Acts as a Cofactor for EBV SM Function


Dinesh Verma



12:30 PM – 2:00 PM Lunch Great Hall
Session 3

2:00 PM – 4:00 PM

Virus Host Interactions I

Session Chairs: Mandy Muller & Ben Gewurz

Shannon Halll
2:00 PM A Genome-wide Screen of EBV Proteins that Modulate Host SUMOylation Identifies a SUMO E3 Ligase conserved in Herpesviruses


Lori Frappier


2:15 PM Computational Analysis of Ribonomics Datasets Identifies Long non-coding RNA targets of γ-herpesviral miRNAs


Rolf Renne


2:30 PM The Receptor or Coreceptors in Epstein-Barr Virus Infection of Nasopharyngeal Epithelial Cells


Mu-sheng Zeng


2:45 PM Examination of the Effects of Rhesus Macaque Rhadinovirus (RRV) Infection and Viral CD200 (vCD200) on Cellular Gene Expression Profiles During in vivo Infection


Ryan D. Estep


3:00 PM PIAS1 restricts Epstein-Barr Virus Reactivation and it is Antagonized by Caspases Upon Lytic Induction


Renfeng Li


3:15 PM Metabolic Reprogramming of Kaposi’s Sarcoma Associated Herpes Virus Infected B-cells in Hypoxia


Rajinish K. Singh


3:30 PM Caspase 3 Activation Facilitates Lytic Replication of Epstein-Barr Virus in Epithelial Cells


Dong-Yan Jin


3:45 PM EBNA3A Regulates Apoptosis at Early and Late Times After Infection in Epstein Barr Virus-Infected B Cells


Joanne Dai


4:00 PM – 4:15 PM Break Shannon Hall Lobby
4:15 PM In memoriam Shannon Hall
4:30 PM Keynote Address II

Blossom Damania

Shannon Hall
5:30 PM – 7:00 PM Dinner Great Hall
7:00 PM – 9:00 PM Poster Session I – Wine/Dessert

Odd-Numbered Posters

Tripp Commons & Main Lounge


Monday, July 30th

7:30 AM- 3:00 PM Registration Annex Room
7:30 AM Coffee Shannon Hall Lobby
Session 4

8:00 AM – 10:00 AM

Lytic Cycle II

Session Chairs: Fanxiu Zhu & Richard Longnecker

Shannon Hall
8:00 AM The EBV Glycoprotein BDLF2 is Essential for the Infection of Stratified Epithelium


Ian Hayman


8:15 AM Kaposi Sarcoma-Associated Herpesvirus gH Is Essential for Viral Infection, but Not for Virion Assembly or Egress from Cells and is an Ideal Target for Vaccine Development


Javier G. Ogembo


8:30 AM An Early Lytic Gene Regulates Immediate Early Gene BZLF1


Xiaofan Li


8:45 AM Immune Mechanisms of Protection Against Latency from Vaccination of a Genetically Engineered Gamma-Herpesvirus


Ting-Ting Wu


9:00 AM How is EBV’s Genome Amplified during its Lytic Cycle?


Thejaswi Nagaraju


9:15 AM The Kaposi’s Sarcoma Herpesvirus Non-Structural Membrane Protein pK15 Recruits the Class II PI3K Phosphatidylinositol 4-phosphate 3-kinase C2 alpha to Activate Productive Viral Replication


Bizunesh Abere Alamirew


9:30 AM CAGE-seq Analysis of Epstein-Barr Virus Lytic Gene Transcription: 3 Kinetic Classes from 2 Mechanisms


Reza Djavadian


9:45 AM Phosphorylation Regulates the Function of the Epstein-Barr virus Pre-Initiation Complex in Transcription of Late Genes


Ayman S. El-Guindy


10:00 AM – 10:30 AM Break Shannon Hall Lobby

Concurrent Sessions

Session 5A

10:30 AM – 12:00 PM

Gene Expression II

Session Chairs: Kenneth Kaye & Lori Frappier

Shannon Hall
10:30 AM Multiple Roles for EBV microRNAs in Regulating EBV Reactivation


Rebecca Skalsky


10:45 AM KSHV vIL-6 Intercellular Signaling Increases Integrin Beta 3 Levels and is Dependent on Activated STAT3


Ricardo Rivera-Soto


11:00 AM Epstein-Barr Virus Nuclear Antigen Leader Protein Co-Activates EP300


Chong Wang


11:15 AM Epstein Barr Virus (EBV) Latency Gene Expression in Solid Organ (SOT) and Bone Marrow (BMT) Post-transplant Lymphoproliferative Disorders (PTLDs)


Amy Chadburn


11:30 AM CRISPR-Cas9 Mediated Knockout of Viral ORF57 Gene from All Copies of the KSHV Genome in BCBL-1 Cells


Zhi-Ming Zheng


11:45 AM The Epstein-Barr Virus BHLF1 Locus Contributes to Viral Latency and B cell Immortalization


Lena Lupey-Green


Session 5B

10:30 AM – 12:00 PM


Session Chairs: Charles Wood & Alan Chiang

Play Circle
10:30 AM Newly Derived endemic Burkitt Lymphoma Cell Lines from Kenyan Patients and the Makings of an Avatar Mouse Model


Ann M. Moormann


10:45 AM Potential Correlates of Mother to Child Transmission in the Humoral Response to KSHV in Zambia


Lisa K. Poppe


11:00 AM Genomic Analyses Support the Association of Pathogenic Variants of Epstein-Barr Virus with Nasopharyngeal Carcinoma


Alan K.S. Chiang


11:15 AM Genome Sequencing Analysis Identifies Epstein-Barr Virus Subtypes Associated with the Risk of Nasopharyngeal Carcinoma


Miao Xu


11:30 AM The Zp-V3 Variant of the Epstein-Barr Virus BZLF1 Promoter Enhances Lytic Reactivation in Response to B-cell Receptor Stimulation and is Over-represented in Burkitt Lymphomas


Jillian A. Bristol


11:45 AM Epstein-Barr Virus (EBV) Serological Profile and Hodgkin Lymphoma (HL) Risk


Zhiwei Liu



12:00 PM – 1:00 PM Lunch Great Hall
1:00 PM Keynote Address III

Bettina Kempkes

Shannon Hall
Session 6

2:00 PM – 3:00 PM


Session Chairs: Denise Whitby & Christian Münz

Shannon Hall
2:00 PM Malaria as a Risk Factor for Early Age of KSHV Infection in a Cohort of Children in Western Kenya


Rosemary Rochford


2:15 PM KSHV Requires EBV for Infection of Peripheral B Cells


Aurélia Faure


2:30 PM Tumor Epstein-Barr Virus Status is Prognostic in Primary Effusion Lymphoma


Kathryn Lurain


2:45 PM Epstein-Barr virus (EBV) Enhances Latent Plasmid Maintenance of Kaposi Sarcoma-associated Herpesvirus (KSHV)


Dirk Dittmer


3:00 PM – 8:00 PM Optional Excursion + Dinner on Own  
8:00 PM – 10:00 PM Poster Session II – Beer/Cheese

Even-Numbered Posters

Tripp Commons & Main Lounge


Tuesday, July 31st

7:30 AM – 5:30 PM Registration Annex Room
7:30 AM Coffee Shannon Hall Lobby
Session 7

8:00 AM – 10:00 AM

Non-Coding RNAs

Session Chairs: Scott Tibbetts & Erik Flemington

Shannon Hall
8:00 AM Misprocessing of Cellular Noncoding RNAs as a Pathway for Cell-Intrinsic Immune Activation


John Karijolich


8:15 AM Identifying EBV microRNA Targets in B-cell Lymphoma and Gastric Cancer Using CLASH


Nathan Ungerleider


8:30 AM Transcriptional Regulation of Viral ncRNAs


Ashley N. Knox


8:45 AM EBV Encoded miR-BART10-3p and miR-BART22 Promote Invasion and Metastasis by Activating Canonical Wnt/β-catenin Signaling Pathway in EBV-Associated Gastric Carcinoma


Chun-kui Shao


9:00 AM A Herpesvirus Utilizes a Sm-class Non-coding RNAs as a miRNA Adaptor to Modulate Host Gene Expression


Demian Cazalla


9:15 AM Impact of Demethylating Agents on Nasopharyngeal Carcinoma Xenografts: de novo Expression of Cp/Wp Transcripts and BHRF1 microRNAs


Pierre Busson


9:30 AM The Secondary Structure of the MHV68 Noncoding RNA TMER4 is Essential for Function at a Critical in vivo Dissemination Bottleneck


Brett A. Hoffman


9:45 AM Epstein Barr virus circRNAome


Erik Flemington


10:00 AM-10:30 AM Break Shannon Hall Lobby

Concurrent Sessions

Session 8A

10:30 AM – 12:00 PM


Session Chairs: Jennifer Totonchy & Maria Masucci

Shannon Hall
10:30 AM EBV Persistence without its EBNA3A and 3C Oncogenes in vivo Anita Murer


10:45 AM G-quadruplexes Regulate mRNA Translation of LANA to Control Antigen Presentation during Latency Prerna Dabral


11:00 AM LMP2A Regulates BART miRNAs Transcription by Translational Activation of ETS Family Genes Hyoji Kim


11:15 AM EBV Latency IIb is Phenotypically Distinct from Latency III Independent of LMP1 Expression Joshua E. Messinger


11:30 AM Uracil DNA Glycosylase of Gammaherpesvirus and Mammals Differentially Support Mutational Outcomes Kevin McBride


11:45 AM Successful Short Term Infection of Humanized Mice with EBV Lacking EBNA3 Genes Contrasts Their Essential Role in B Cell Transformation In Vitro and Their Role in Favouring Latency in Memory B Cells Christine T. Styles


12:00 PM Enhancement of in vivo Latency by Substitution of the KSHV LANA DNA Binding Domain with that of MHV68 in Chimeric Virus Kenneth M. Kaye


12:15 PM Identification of ARKL1 as a Jun-interacting Factor that Negatively Regulates EBV Reactivation Umama Zia Siddiqi


Session 8B

10:30 AM – 12:00 PM

Virus-Host Interactions II

Session Chairs: Britt Glaunsinger & Yasuaki Harabuchi

Play Circle
10:30 AM Role of KSHV in T cell Infiltration in Kaposi’s Sarcoma Microenvironment Yan Yuan


10:45 AM Epstein-Barr virus LMP1 Hijacks the Host ESCRT Machinery for Exosomal Secretion Dingani Nkosi


11:00 AM vIRF-1 Regulates Mitochondrial Content by Promoting Mitophagy during HHV-8 Replication Mai Tram Vo


11:15 AM Epstein-Barr Virus Activates F-box Protein FBXO2 to Limit Viral Infectivity by Targeting Glycoprotein B for Degradation Lin Feng


11:30 AM Cell-Mediated Immune Responses to Persistent KSHV Infection in Mice with Reconstituted Human Immune System Components Nicole Caduff


11:45 AM Epstein-Barr Virus Infection Promotes Epithelial Cell Growth by Attenuating Differentiation-Dependent Exit from Cell Cycle Mark R. Eichelberg


12:00 PM IFN-ƴ Responses in Peripheral Blood Lymphocytes of Patients with KSHV-associated Diseases Treated with Pomalidomide and Liposomal Doxorubicin Kathryn Lurain


12:15 PM Epstein-Barr Virus-Infected Tonsillar Marginal Zone B Cells in vivo as a Precursor for Immunosuppression-Related B-cell Lymphoma Charles Torgbor



12:30 PM – 1:00 PM General EBV Association Meeting Shannon Hall
12:30 PM – 1:30 PM Lunch Great Hall
Session 9

1:30 PM – 3:00 PM


Session Chairs: Thomas Schulz & Micah Luftig

Shannon Hall
1:30 PM Increased Association Between EBV EBNA2 From Type 2 Strains And The Transcriptional Repressor BS69 Restricts B Cell Growth


Michelle J. West


1:45 PM The Oncogenic Kaposi’s Sarcoma-Associated Herpesvirus Encodes a Mimic of the Tumor Suppressor miR-16


Kylee Morrison


2:00 PM Role of mTOR Complexes in the Maintenance of Nasopharyngeal Carcinoma Cancer Stem Cells


Nannan Zhu


2:15 PM An Essential Role of Urea Cycle and Argininosuccinate Synthase 1 in KSHV-induced Cellular Transformation


Tingting Li


2:30 PM Reverse Engineering EBV Driven B Cell Transformation and Lymphomagenesis in the Mouse


Thomas Sommermann


2:45 Pm An EBNA3C-deleted Epstein-Barr virus (EBV) Mutant Causes B-cell Lymphomas with Delayed onset in a Cord Blood-Humanized Mouse Model


James Romero-Masters


3:00 PM – 3:30 PM Break Shannon Hall Lobby

Concurrent Sessions

Session 10A

3:30 PM – 5:00 PM

Immunity & Immune Therapy

Session Chairs: Dirk Dittmer & Rajiv Khanna

Shannon Hall
3:30 PM A Role for EBNA2 in Mechanisms that Foster Some Autoimmune Diseases


John B. Harley


3:45 PM Disruption of IL-15 Signaling and NK cells Facilitates Oncogenesis of Gammaherpesviruses in SIV-Infected Rhesus Macaques


Yoshinori Fukazawa


4:00 PM Dramatically Decreased and Delayed CD8 T-Cell Responses during Asymptomatic EBV Seroconversion


Liisa K. Selin


4:15 PM Gammaherpesvirus Infected B Cells Display Abnormal Repertoire


Monika Zelazowska


4:30 PM Defective EBV Particles equipped with Latent Epitopes offer Increased Protection Against EBV Infection


Dwain van Zyl


4:45 PM Candidate Public T-Cell Responses to Kaposi sarcoma Identified through T-Cell Receptor Sequencing of Tumor Infiltrating Lymphocytes


Warren Phipps


Session 10B

3:30 PM – 5:00 PM

Virus-Host Interactions II

Session Chairs: Hongyu Deng & Cliona Rooney

Play Circle
3:30 PM The KSHV Protein ORF68 is a Proteasome-Manipulating Nuclease Required for DNA Packaging


Matthew Gardner


3:45 PM Epstein-Barr Virus Nuclear Antigen-1, Action and Reaction as an Oncogene


Joanna Wilson


4:00 PM Genome-wide Identification of Direct RTA Targets Reveals Key Host Factors for KSHV Lytic Reactivation


Bernadett Papp


4:15 PM EBV Lytic Replication in mTOR-Inhibited Epithelial Cells is Correlated with YY1 and Mnk1/2 Activities


Amy L. Adamson


4:30 PM Interferon-Stimulated Gene Product RNF213 Modulates KSHV Lytic Replication and Latency via Targeting RTA


Hongyu Deng


4:45 PM An Analog Sensitive Derivative of the Epstein Barr Virus v-Cdk Permits the Direct Identification of Substrates Participating in Multiple Stages of Gene Expression


Robert F. Kalejta


5:00 PM – 7:00 PM Joint Reception of EBV & KSHV Meeting with DNA Tumor Viruses Meeting Great Hall
7:00 PM Keynote Address IV

Douglas Lowy

Shannon Hall

Wednesday, August 1st

8:00 AM – 5:00 PM Registration Annex Room
8:00 AM Coffee Shannon Hall Lobby
Session Topic

9:00 AM – 10:30 AM

Joint Session #1

Session Chairs: Erle Robertson & Elizabeth White

Shannon Hall
9:00 AM Point-of-Care Detection of KSHV and EBV to diagnose Kaposi sarcoma and endemic Burkitt lymphoma


Ethel Cesarman


9:30 AM The Chemokine CXCL14 Suppresses HPV-positive Head and Neck Cancer through the Antigen-Specific CD8+ T Cell Response


Dohun Pyeon


9:45 AM Development of a Humanized Mouse Model to Dissect the Role of T-cells in Epstein-Barr Virus Type 2 Latency and Lymphomagenesis


Carrie Coleman


10:00 AM Repair of E6/E7 induced Breaks in Viral Genomes Leads to Amplification


Laimonis Laimins


10:15 AM EBV gH/gL nanoparticle vaccines elicit antibodies that potently inhibit EBV glycoprotein-mediated B cell and epithelial cell membrane fusion and neutralize virus infection


Jeffrey Cohen


10:30 AM Break Shannon Hall Lobby
Session Topic

11:00 AM – 12:30 PM

Joint Session #2

Session Chairs: Jeffrey Cohen & Miranda Thomas

Shannon Hall
11:00 AM Local Dysregulation of the Immune Response Impairs Immunotherapy for HPV Associated Premalignancy


Ian Frazer


11:30 AM A Novel Virus Counteraction Mechanism against APOBEC3-Mediated Hypermutation and Restriction


Adam Cheng


11:45 AM Apobec3A is a Novel Restriction Factor Antagonizing Efficient HAdV Replication


Julia Mai


12:00 PM The Enzymatic Activities of the Viral dUTPase and Viral uracil-DNA Glycosylase Stabilize the Gammaherpesvirus Genome and Promote Pathogenesis in the Host


Laurie Krug


12:15 PM Epstein-Barr Virus Deubiquitinase BPLF1 Targets the RIG-I Signalosome to Inhibit the IFN Response


Maria G. Masucci


12:30 PM – 2:00 PM Lunch Great Hall































August 1 Wednesday Afternoon  
Session Topic

2:00 PM – 3:30 PM

Joint Session #3

Session Chairs: Michelle West & Doug Lowy

Shannon Hall
2:00 PM EBV-Induced Metabolic Dependency Factors in B-cell Transformation


Ben Gewurz


2:30 PM Identifying Genome-Wide Targets of the Late Gene Transcription Complex in KSHV


Divya Nandakumar


2:45 PM High Risk a-HPV Oncogenes Induce and Disrupt Tranlesion Synthesis


Sebastian Wendel


3:00 PM High Risk HPV Oncogenes Impair the Fanconi Anemia DNA Repair Pathway


Sujita Khanal


3:15 PM Structure-Guided Identification of Interaction Hotspot for Developing Inhibitors Interrupting KSHV Capsid Assembly


Danyang Gong


3:30 PM Break Shannon Hall Lobby
Session Topic

4:00 PM – 5:30 PM

Joint Session #4

Session Chairs: Laurie Krug & Bettie Steinberg

Shannon Hall
4:00 PM Discovery and characterization of human γ-Herpesvirus-circular RNAs


Tuna Toptan


4:15 PM Human and Viral Circular RNAs during Infection


Takanobu Tagawa


4:30 PM High-Risk HPV E7 Proteins Degrade the Tumor Suppressor PTPN14 to Limit Keratinocyte Differentiation


Elizabeth White


4:45 PM Human Papillomavirus E7 Oncoprotein Promotes the Epstein-Barr Virus Lytic Life Cycle in Immortalized Oral Keratinocytes


Kathleen Makielski


5:00 PM Inhibition of Epstein-Barr Virus Replication in Human Papillomavirus-Immortalized Keratinocytes


Joseph Guidry


5:15 PM EBV Hijacks PARP1 Activity to Control Both the Viral and Cellular Epigenome


Italo Tempera


6:00 PM – 9:00 PM Closing Banquet Great Hall
9:00 PM – 11:00 PM Dance Great Hall





Key Note Speakers

Blossom Damania, Ph.D.
University of North Carolina Chapel Hill 

Bettina Kempkes, Prof. Dr.
Helmholtz Center Munich

Paul M. Lieberman, Ph.D.
The Wistar Institute

Doug Lowy, M.D.
Center for Cancer Research 
National Cancer Institute