The DNA Conference will take place at Memorial Union on the University of Wisconsin – Madison campus.
July 31 | Tuesday | |
12:00 PM – 7:00 PM | Registration | Annex Room |
5:00 PM – 7:00 PM | Joint Reception with EBV/KSHV | Great Hall |
7:00 PM | Joint Session 1: Keynote Address
Douglas Lowy |
Shannon Hall |
August 1 | Wednesday | |
7:30 AM – 5:00 PM | Registration | Annex Room |
7:30 AM – 8:30 AM | Breakfast | Lobby |
9:00 AM | Joint Session with EBV/KSHV
Co-Chair: Elizabeth White |
Shannon Hall |
9:00 AM | Point-of-Care Detection of KSHV and EBV to Diagnose Kaposi Sarcoma and Endemic Burkitt Lymphoma | Ethel Cesarman |
9:30 AM | The Chemokine CXCL14 Suppresses HPV-positive Head and Neck Cancer through the Antigen-Specific CD8+ T Cell Response | Dohun Pyeon |
9:45 AM | Development of a Humanized Mouse Model to Dissect the Role of T-cells in Epstein-Barr Virus Type 2 Latency and Lymphomagenesis | Carrie Coleman |
10:00 AM | Repair of E6/E7 Induced Breaks in Viral Genomes Leads to Amplification | Lou Laimins |
10:15 AM | EBV gH/gL Nanoparticle Vaccines Elicit Antibodies that Potently Inhibit EBV Glycoprotein-Mediated B Cell and Epithelial Cell Membrane Fusion and Neutralize Virus Infection | Jeffrey Cohen |
10:30 AM – 11:00 AM | Refreshment Break | Lobby |
11:00 AM | Joint Session with EBV/KSHV
Co-Chair: Miranda Thomas |
Shannon Hall |
11:00 AM | Local Dysregulation of the Immune Response Impairs Immunotherapy for HPV Associated Premalignancy | Ian Frazer |
11:30 AM | A Novel Virus Counteraction Mechanism Against APOBEC3-mediated Hypermutation and Restriction | Adam Cheng |
11:45 AM | Apobec3A is a Novel Restriction Factor Antagonizing Efficient HAdV Replication | Julia Mai |
12:00 PM | The Enzymatic Activities of the Viral dUTPase and Viral uracil-DNA Glycosylase Stabilize the Gammaherpesvirus Genome and Promote Pathogenesis in the Host | Laurie Krug |
12:15 AM | Epstein-Barr Virus Deubiquitinase BPLF1 Targets the RIG-I Signalosome to Inhibit the IFN Response | Maria G. Masucci |
12:30 PM – 2:00 PM | Lunch Buffet | Great Hall |
2:00 PM | Joint Session with EBV/KSHV
Co-Chair: Doug Lowy |
Shannon Hall |
2:00 PM | EBV-Induced Dependency Factors in B-cell Transformation | Ben Gewurz |
2:30 PM | Identifying Genome-Wide Targets of the late gene Transcription Complex in KSHV | Divya Nandakuma |
2:45 PM | High Risk α-HPV Oncogenes Induce and Disrupt Translesion Synthesis | Sebastian Wendel |
3:00 PM | High Risk HPV Oncogenes Impair the Fanconi Anemia DNA Repair Pathway | Sujita Khanal |
3:15 PM | Structure-Guided Identification of Interaction Hotspot for Developing Inhibitors Interrupting KSHV Capsid Assembly | Danyang Gong |
3:30 PM – 4:00 PM | Refreshment Break | Lobby |
4:00 PM | Joint Session with EBV/KSHV
Co-Chair: Bettie Steinberg |
Shannon Hall |
4:00 PM | Discovery and Characterization of Human gHerpesvirus-Circular RNAs | Tuna Toptan |
4:15 PM | Human and Viral Circular RNAs During Infection | Takanobu Tagawa |
4:30 PM | High-Risk HPV E7 Proteins Degrade the Tumor Suppressor PTPN14 to Limit Keratinocyte Differentiation | Elizabeth White |
4:45 PM | Human Papillomavirus E7 Oncoprotein Promotes the Epstein-Barr Virus Lytic Life Cycle in Immortalized Oral Keratinocytes | Kathleen Makielski |
5:00 PM | Inhibition of Epstein-Barr Virus Replication in Human Papillomavirus-Immortalized Keratinocytes | Joseph Guidry |
5:15 PM | EBV Hijacks PARP1 Activity to Control Both the Viral and Cellular Epigenome. | Italo Tempera |
6:00 PM – 8:00 PM | Dinner | Tripp Commons |
August 2 | Thursday | |
7:30 AM – 5:00 PM | Registration | Annex Room |
7:30 AM – 8:30 AM | Breakfast | Lobby |
8:30 AM | Oral Session I
Part 1: Infection/Life Cycle Session Chairs: Susa Wells and Michell Ozbun |
Shannon Hall |
8:30 AM | E7 Protein is Required for p53 Degradation during Natural HPV16 Infection | Martin Sapp |
8:45 AM | Role of Chromatin Modifications in Human Papillomavirus Infection of Primary Human Keratinocytes | Samuel Porter |
9:00 AM | SAMHD1 and the HPV16 Life Cycle | Claire James |
9:15 AM | Human Papillomavirus Type 18 E6 Oncoprotein Interacts with the Protein Kinase A-anchoring Protein AKAP95 | Paul McCormack |
9:30 AM | EGFR Signaling is a Critical Regulator of HPV16 Oncogene Expression | Adrian Luna |
9:45 AM | E4orf3 Dependent Modulation of Hypoxia Pathways During HAdV Infection | Sawinee Masser |
10:00 AM | Opportunistic oral HPV Infections in HIV/AIDS: Primary human Three-Dimensional Tissue Treated with HIV Protease Inhibitors is Permissive to HPV16 Infection and Progeny Virion Biosynthesis | Samina Alam |
10:15 AM | Refreshment Break | Lobby |
10:45 AM | Part 2: Virus Host Interactions | Shannon Hall |
10:45 AM | An Epigenetic Echo Persists after Leukemic Fusion Genes Expel Adenovirus from a Human B Lymphocytic Cell Line | David Ornelles |
11:00 AM | Tissue Specific Pathways Critical for Oncogenic Human Papillomavirus Pathogenesis | Sreejata Chatterjee |
11:15 AM | NHERF1 is Targeted for Degradation by E6 Proteins from Both High- and Low-risk Human Papillomaviruses | Camille Drews |
11:30 AM | MicroRNAS Regulate HPV16 L1 RNA Splicing by Interacting with RNA CIS-Elements | Zhi-Ming Zheng |
11:45 AM | Regulation of Interleukin-36γ (IL-36γ) Expression and Release in Normal Keratinocytes and Respiratory Papilloma Cells | Bettie Steinberg |
12:00 PM | A SIRT1-WRN Axis Regulates the Quantity and Fidelity of HPV16 DNA Replication | Dipon Das |
12:15 PM | Role of histone variant macroH2A1 in Human papillomavirus infection | Simran Khurana |
12:30 PM – 2:00 PM | Lunch Buffet | Great Hall |
2:00 PM | Oral Session II
Part 1: Transcription Session Chairs: Rachel Katzenellenbogen and Louise Chow |
Shannon Hall |
2:00 PM | Activation of ATP-sensitive Potassium Channels (KATP) by High-Risk HPV is Critical for Cervical Cancer Proliferation and Transformation | Andrew Macdondald |
2:15 PM | Chromatin Accessibility and Histone Modification Dynamics Influence Late Gene Expression of KSHV | Carolina Arias |
2:30 PM | A Crosstalk Between the Epigenetic Enzyme KDM2B and Epstein-Barr Virus Infection | Rosita Accardi |
2:45 PM | Construction of a Complete Transcript Map for Cottontail Rabbit Papillomavirus | Pengfei Jiang |
3:00 PM | Mechanisms of Tandem Repeat Formation at HPV Integration Sites in Cervical Carcinoma Cells | Alix Warburton |
3:15 PM | CTCF Regulates the Epigenetic Landscape of the Human Papillomavirus Enhancer to Control Differentiation-Dependent Early Viral Gene Expression | Karen Campos |
3:30 PM | SV40 Encapsidation Directs Chromatin Remodeling by Nucleosome Sliding and Genomic Spread of Histone Modifications | Barry Milavetz |
3:45 PM – 4:00 PM | Refreshment Break | Lobby |
4:00 PM | Part 2: Transformation | Shannon Hall |
4:00 PM | NFX1-123 Expression is Increased During Differentiation and is Required for Targeted Differentiation Pathway Activation While Maintaining Growth in 16E6-expressing Keratinocytes | Rachel Katzenellenbogen |
4:15 PM | Characterization of a Novel Epstein-Barr Virus Protein that is Expressed in Gastric Carcinoma and Inhibits the DNA Damage Response | Lori Frappier |
4:30 PM | β-HPV E6 Inhibits Hippo Pathway Activation Following Failed Cytokinesis | Dalton Dacus |
4:45 PM | Growth Potential and Apoptosis is Inhibited by Localised Topical Microwave Energy in HPV16-positive Cervical Tumour Cells of 3D Organotypic Raft Cultures | Michaela Conley |
5:00 PM | HPV Oncoproteins Promote Expression of Long Noncoding RNA lnc-FANCI-2 via YY1 and miR-29a | Haibin Liu |
5:15 PM | HPV16 E6 and E7 Hypersensitize Head and Neck Tumors to WEE1 Inhibition through Forced Mitotic Entry, Elevated Replication Stress and Defective DNA Damage Response | Ahmed Diab |
5:30 PM | E6 from Oncogenic HPV Strains Recruits USP46 to Stabilize Cdt2 and Promote Cell Proliferation | Shashi Kiran |
5:45 PM | The Relationship Between Pre-cancerous Cervical Lesions, HIV, and the Cervical Microbiome | Cameron Klein |
6:00 PM | Dinner | Great Hall |
8:00 PM – 10:00 PM | Poster Session – Odd Numbered | Tripp Commons |
August 3 | Friday | |
7:30 AM – 5:00 PM | Registration | Annex Room |
7:30 AM – 8:30 AM | Breakfast | Lobby |
8:30 AM | Oral Session III
Part 1: Virus Host Interactions Session Chairs: Ian Frazer and Sheila Graham |
Shannon Hall |
8:30 AM | The HPV E6 PDZ Binding Motif links DNA Damage Response Signaling to E6 Inhibition of p53 Transcriptional Activity | Lawrence Banks |
8:45 AM | Identification of Differential Gene Expression of a Potential Novel Candidate Tumor Suppressor Gene on Chromosome 11q13 in Non-Tumorigenic and Tumorigenic HeLa x Fibroblast Hybrid Cells | Kerstin Maria Lowinski |
9:00 AM | Furin-Dependent Oligomerization of L2 | Shuaizhi Li |
9:15 AM | Adenovirus Oncogene Product Small E1A Protein Stimulates HBO1 (Myst2) Acetylase Activity | Bayar Thimmapaya |
9:30 AM | The Effect of Productive HPV16 Infection on Global Gene Expression of Cervical Epithelium | Sa Do Kang |
9:45 AM | Therapeutic Target Discovery in Pediatric Recurrent Respiratory Papillomatosis | Marion Brusadelli |
10:00 AM | Cellular Metabolic Changes Associated with ΔE1A Human Adenovirus Infection | Martin Prusinkiewicz |
10:15 AM
10:30 AM – 11:00 AM |
Metabolic Profiling of the HPV16 Infected Epidermis
Refreshment Break |
Kanimozhi Vairamani
Lobby |
11:00 AM | Part 2: Infection/Life Cycle, Immunology | Shannon Hall |
11:00 AM | Viral Attachment and Entry: An Opportunity to Understand and Prevent HPV Infections | Jesse Young |
11:15 AM | Using Novel Inhibitors of BK Polyomavirus to Investigate Viral Entry Mechanisms | Joshua Kane |
11:30 AM | Sneaking Past cGAS/STING: Pathway Regulation by Mitotic Golgi Dispersal | Brittany Forte |
11:45 AM | Host Gene Expression Response to BKV Infection is Cell Type Specific | Ping An |
12:00 PM | Dissecting the Inflammatory Response to Merkel Cell Polyomavirus Infection | Nathan Krump |
12:15 PM | Development of a Virus-Like Particle Vaccine Against BK and JC Polyomaviruses | Alberto Peretti |
12:30 PM | Development of Single-Domain Antibodies Targeting the Human Papillomavirus 16 E6 Protein | Guillem Dayer |
12:45 PM | Dendritic Tropism of Mouse Polyomavirus (MuPyV) Limits Viral Spread and CD8 T Cell Response | Qingsong Qin |
1:00 PM – 2:30 PM | Lunch Buffet | Great Hall |
2:30 PM | Oral Session IV
Part 1: Virus Host Interactions/Replication Session Chairs: Massimo Tommasino and Cary Moody |
Shannon Hall |
2:30 PM | HDAC Inhibitors Abrogate Productive HPV DNA Amplification in Raft Cultures of Primary Human Keratinocytes (PHKs) | Louise Crew |
2:45 PM | Temporal Recruitment of PML Nuclear Body-Residing Proteins to Incoming HPV Genomes Following Nuclear Delivery | Lucile Guion |
3:00 PM | Regulation of Stromal Type I Interferons by Human Papillomavirus Type 16 | Jason Bodily |
3:15 PM | Regulation of Innate Immune Signaling by Human Papillomavirus 16 E5 | Matthew Scott |
3:30 PM | MCPyV Replicative Stress Induces Senescence in Neonatal Dermal Fibroblasts in a Kap1-Dependent Manner | Svenja Siebels |
3:45 PM | Dual Inhibition of MDM2 and MDM4 in Virus-Positive Merkel Cell Carcinoma Enhances the p53 Response | Donglim Esther Park |
4:00 PM – 4:30 PM | Refreshment Break | Lobby |
4:30 PM | Part 2: Replication | Shannon Hall |
4:30 PM | HPV: The First Virus Known to Use All Three Cellular DNA Replication Polymerases in Its ‘Lytic’ Replication Cycle | Thomas Melendy |
4:45 PM | Murine Polyomavirus Replication Centers Contain Discrete Nanoscale Subdomains | Doug Peters |
5:00 PM | Interaction of the HPV E1 Helicase with UAF1-USP1 Promotes Viral Genome Replication through the Synthesis of Non-Theta DNA Intermediates | Marit Orav |
5:15 PM | Non-Human Primate Papillomaviruses as a Potential Model System for Anti-HPV Drug Testing | Eva-Maria Tombak |
5:30 PM | Replication of HPV Genomes Proceeds Via Distinct Mechanisms | Marko Piirsoo |
5:45 PM | Temporal Dynamics of Adenovirus Gene Expression | Leandro Cristomo |
6:00 PM | NVN1000, a Novel Nitric Oxide Releasing Compound, Reduces HPV-18 E6 and E7 activities and Inhibits viral DNA Amplification and Virus Production in Epithelial Raft Cultures | Nilam Sanjib Banerjee |
6:15 PM – 8:30 PM | Dinner | Great Hall |
8:30 PM – 10:30 PM | Poster Session – Even Numbered | Tripp Commons |
August 4 | Saturday | |
7:30 AM – 5:00 PM | Registration | Annex Room |
7:30 AM – 8:30 AM | Breakfast | Lobby |
8:30 AM | Oral Session V
Part 1: Replication Session Chairs: Alison McBride and Nicholas Wallace |
Shannon Hall |
8:30 AM | The Anti-Splicing Drug SRPIN340 Inhibits Human Papillomavirus E2 Expression and Viral Replication in Raft Culture | Sheila Graham |
8:45 AM | Viral Transcriptional Enhancer Cis Elements are Necessary for HPV18 Maintenance Replication | Tami Coursey |
9:00 AM | The Role of Protein Kinase CK2 in HPV Replication | Marko Piirsoo |
9:15 AM | Analysis of HPV16 E1-E2 DNA Replication in Oropharyngeal Cancer Cell Lines | Molly Bristol |
9:30 AM | Phosphorylation of Tyrosine 138 in Human Papillomavirus 31 E2 Protein Regulates Brd4 Binding and Viral Genome Replication | Leny Jose |
9:45 AM | Kinase Activity of Fibroblast Growth Factor Receptors Regulate Activity of the Papillomavirus E2 Protein | Marsha DeSmet |
10:00 AM | E6 Mediated STAT3 Activation Occurs Via an NFκB-IL-6-JAK2 Signalling Axis in HPV Positive Cervical Cancer | Ethan Morgan |
10:15 AM – 10:45 AM | Refreshment Break | Lobby |
10:45 AM | Part 2 Transformation | Shannon Hall |
10:45 AM | E6 and E7 from Beta HPV38 and HPV49 Display Different Biological Properties in Transgenic Animal Models | Massimo Tommasino |
11:00 AM | MCPyV T Antigens and their Association with the Fbw7 Ubiquitin Ligase | Ann Roman |
11:15 AM | Prevention of Cervical Cancer by Progestin in the HPV Transgenic Mouse Model | Seung Han Baik |
11:30 AM | Activating Mutations in Pik3ca Contribute to Anal Carcinogenesis in the Presence and Absence of HPV16 Oncogenes | Myeoungkyun Shin |
11:45 AM | Treatment-Naïve HPV+ Head and Neck Cancers Display a T-cell-Inflamed Phenotype Distinct from Their HPV- Counterparts That Has Implications for Immunotherapy | Steven Gameiro |
12:00 PM | Merkel Cell Polyomavirus ST Activates MAPK Signalling to Enhance Tumourigenesis | Samuel Dobson |
12:15 PM – 2:00 PM | Lunch Buffet | Great Hall |
2:00 PM | Oral Session VI
Part 1: Transformation Session Chairs: Evie Carchman and Ann Roman |
Shannon Hall |
2:00 PM | HPV E4 and E5 Expression in Head and Neck Cancer is Associated with Immune Cell Infiltration | James Pipas |
2:15 PM | Merkel Cell Polyomavirus Large T Antigen Activates the Enhancer of Zeste Homolomogue 2 Expression in Merkel Cell Carcinoma | Masahiro Shuda |
2:30 PM | Role of IQGAP1 in HPV-positive Head and Neck Carcinogenesis | Tao Wei |
2:45 PM | Dysregulation of Cellular Long Noncoding RNAs in Response to HPV Oncogene Expression | Surendra Sharma |
3:00 PM | Role of the Merkel Cell Polyomavirus (MCPyV) Tumor Antigens in Tumor Development | Megan Spurgeon |
3:15 PM | High-Risk Human Papillomaviruses Downregulate Expression of the Ste20 Family Kinase MST1 to Inhibit the Hippo Pathway and Promote Oncogenesis | Ethan Morgan |
3:30 PM | Destabilization of TIP60 by Oncoviruses: From Mechanism to Significance | Sudhakar Jha |
3:45 PM – 4:00 PM | Refreshment Break | Lobby |
4:00 PM | Regulation of Archetype BK Polyomavirus Late Gene and miRNA Expression | Wei Zou |
4:15 PM | Short Half-Life of HPV16 E6 and E7 mRNAs Sensitizes HPV16-Positive Tonsillar Cancer Cells to DNA-Damaging Drugs | Kersti Nilsson |
4:30 PM | Papillomaviruses and Polyomaviruses Associated with Non-Mammalian Hosts Provide Insights into the Evolution of Viral Oncogenes | Koenraad Van Doorslaer |
4:45 PM | Proteomic Pathogen discovery – A Proof-of-Principle Study Using FFPE Tissue and Label-Free Differential Mass Spectrometry | Tuna Toptan |
5:00 PM | Detection of DNA tumor Viruses in Early-Stage Urothelial Carcinoma | Gabriel Starrett |
5:15 PM | Integration of Mouse Papillomavirus Type 1 (MmuPV1) Occurs Often in Benign Tumor | Lulu Yu |
5:30 PM | BK Polyomavirus microRNA Expression and Sequence Variation in Polyomavirus-Associated Nephropathy | Hanna Seppälä |
5:45 PM | Gene Editing Using Cripsr/Cas is Highly Effective in Vivo for HPV-Driven Cancers | Nigel Mcmillan |
6:30 PM | Banquet Dinner | Great Hall |
8:30 PM | Dance | Tripp Commons |