Schedule

The DNA Conference will take place at Memorial Union on the University of Wisconsin – Madison campus.

July 31 Tuesday  
12:00 PM – 7:00 PM Registration Annex Room
5:00 PM – 7:00 PM Joint Reception with EBV/KSHV Great Hall
7:00 PM Joint Session 1: Keynote Address

Douglas Lowy

Shannon Hall

 

 

August 1 Wednesday  
7:30 AM – 5:00 PM Registration Annex Room
7:30 AM – 8:30 AM Breakfast Lobby
9:00 AM Joint Session with EBV/KSHV

Co-Chair: Elizabeth White

Shannon Hall
9:00 AM Point-of-Care Detection of KSHV and EBV to Diagnose Kaposi Sarcoma and Endemic Burkitt Lymphoma Ethel Cesarman
9:30 AM The Chemokine CXCL14 Suppresses HPV-positive Head and Neck Cancer through the Antigen-Specific CD8+ T Cell Response Dohun Pyeon
9:45 AM Development of a Humanized Mouse Model to Dissect the Role of T-cells in Epstein-Barr Virus Type 2 Latency and Lymphomagenesis Carrie Coleman
10:00 AM Repair of E6/E7 Induced Breaks in Viral Genomes Leads to Amplification Lou Laimins
10:15 AM EBV gH/gL Nanoparticle Vaccines Elicit Antibodies that Potently Inhibit EBV Glycoprotein-Mediated B Cell and Epithelial Cell Membrane Fusion and Neutralize Virus Infection Jeffrey Cohen
10:30 AM – 11:00 AM Refreshment Break Lobby
11:00 AM Joint Session with EBV/KSHV

Co-Chair: Miranda Thomas

Shannon Hall
11:00 AM Local Dysregulation of the Immune Response Impairs Immunotherapy for HPV Associated Premalignancy Ian Frazer
11:30 AM A Novel Virus Counteraction Mechanism Against APOBEC3-mediated Hypermutation and Restriction Adam Cheng
11:45 AM Apobec3A is a Novel Restriction Factor Antagonizing Efficient HAdV Replication Julia Mai
12:00 PM The Enzymatic Activities of the Viral dUTPase and Viral uracil-DNA Glycosylase Stabilize the Gammaherpesvirus Genome and Promote Pathogenesis in the Host Laurie Krug
12:15 AM Epstein-Barr Virus Deubiquitinase BPLF1 Targets the RIG-I Signalosome to Inhibit the IFN Response Maria G. Masucci
12:30 PM – 2:00 PM Lunch Buffet Great Hall
2:00 PM Joint Session with EBV/KSHV

Co-Chair: Doug Lowy

Shannon Hall
2:00 PM EBV-Induced Dependency Factors in B-cell Transformation Ben Gewurz
2:30 PM Identifying Genome-Wide Targets of the late gene Transcription Complex in KSHV Divya Nandakuma
2:45 PM High Risk α-HPV Oncogenes Induce and Disrupt Translesion Synthesis Sebastian Wendel
3:00 PM High Risk HPV Oncogenes Impair the Fanconi Anemia DNA Repair Pathway Sujita Khanal
3:15 PM Structure-Guided Identification of Interaction Hotspot for Developing Inhibitors Interrupting KSHV Capsid Assembly Danyang Gong
3:30 PM – 4:00 PM Refreshment Break Lobby
4:00 PM Joint Session with EBV/KSHV

Co-Chair: Bettie Steinberg

Shannon Hall
4:00 PM Discovery and Characterization of Human gHerpesvirus-Circular RNAs Tuna Toptan
4:15 PM Human and Viral Circular RNAs During Infection Takanobu Tagawa
4:30 PM High-Risk HPV E7 Proteins Degrade the Tumor Suppressor PTPN14 to Limit Keratinocyte Differentiation Elizabeth White
4:45 PM Human Papillomavirus E7 Oncoprotein Promotes the Epstein-Barr Virus Lytic Life Cycle in Immortalized Oral Keratinocytes Kathleen Makielski
5:00 PM Inhibition of Epstein-Barr Virus Replication in Human Papillomavirus-Immortalized Keratinocytes Joseph Guidry
5:15 PM EBV Hijacks PARP1 Activity to Control Both the Viral and Cellular Epigenome. Italo Tempera
6:00 PM – 8:00 PM Dinner Tripp Commons

 

August 2 Thursday  
7:30 AM – 5:00 PM Registration Annex Room
7:30 AM – 8:30 AM Breakfast Lobby
8:30 AM Oral Session I

Part 1: Infection/Life Cycle

Session Chairs: Susa Wells and Michell Ozbun

Shannon Hall
8:30 AM E7 Protein is Required for p53 Degradation during Natural HPV16 Infection Martin Sapp
8:45 AM Role of Chromatin Modifications in Human Papillomavirus Infection of Primary Human Keratinocytes Samuel Porter
9:00 AM SAMHD1 and the HPV16 Life Cycle Claire James
9:15 AM Human Papillomavirus Type 18 E6 Oncoprotein Interacts with the Protein Kinase A-anchoring Protein AKAP95 Paul McCormack
9:30 AM EGFR Signaling is a Critical Regulator of HPV16 Oncogene Expression Adrian Luna
9:45 AM E4orf3 Dependent Modulation of Hypoxia Pathways During HAdV Infection Sawinee Masser
10:00 AM Opportunistic oral HPV Infections in HIV/AIDS: Primary human Three-Dimensional Tissue Treated with HIV Protease Inhibitors is Permissive to HPV16 Infection and Progeny Virion Biosynthesis Samina Alam
10:15 AM Refreshment Break Lobby
10:45 AM Part 2: Virus Host Interactions Shannon Hall
10:45 AM An Epigenetic Echo Persists after Leukemic Fusion Genes Expel Adenovirus from a Human B Lymphocytic Cell Line David Ornelles
11:00 AM Tissue Specific Pathways Critical for Oncogenic Human Papillomavirus Pathogenesis Sreejata Chatterjee
11:15 AM NHERF1 is Targeted for Degradation by E6 Proteins from Both High- and Low-risk Human Papillomaviruses Camille Drews
11:30 AM MicroRNAS Regulate HPV16 L1 RNA Splicing by Interacting with RNA CIS-Elements Zhi-Ming Zheng
11:45 AM Regulation of Interleukin-36γ (IL-36γ) Expression and Release in Normal Keratinocytes and Respiratory Papilloma Cells Bettie Steinberg
12:00 PM A SIRT1-WRN Axis Regulates the Quantity and Fidelity of HPV16 DNA Replication Dipon  Das
12:15 PM Role of histone variant macroH2A1 in Human papillomavirus infection Simran Khurana
12:30 PM – 2:00 PM Lunch Buffet Great Hall
2:00 PM Oral Session II

Part 1: Transcription

Session Chairs: Rachel Katzenellenbogen and Louise Chow

Shannon Hall
2:00 PM Activation of ATP-sensitive Potassium Channels (KATP) by High-Risk HPV is Critical for Cervical Cancer Proliferation and Transformation Andrew Macdondald
2:15 PM Chromatin Accessibility and Histone Modification Dynamics Influence Late Gene Expression of KSHV Carolina Arias
2:30 PM A Crosstalk Between the Epigenetic Enzyme KDM2B and Epstein-Barr Virus Infection Rosita Accardi
2:45 PM Construction of a Complete Transcript Map for Cottontail Rabbit Papillomavirus Pengfei Jiang
3:00 PM Mechanisms of Tandem Repeat Formation at HPV Integration Sites in Cervical Carcinoma Cells Alix Warburton
3:15 PM CTCF Regulates the Epigenetic Landscape of the Human Papillomavirus Enhancer to Control Differentiation-Dependent Early Viral Gene Expression Karen Campos
3:30 PM SV40 Encapsidation Directs Chromatin Remodeling by Nucleosome Sliding and Genomic Spread of Histone Modifications Barry Milavetz
3:45 PM – 4:00 PM Refreshment Break Lobby
4:00 PM Part 2: Transformation Shannon Hall
4:00 PM NFX1-123 Expression is Increased During Differentiation and is Required for Targeted Differentiation Pathway Activation While Maintaining Growth in 16E6-expressing Keratinocytes Rachel Katzenellenbogen
4:15 PM Characterization of a Novel Epstein-Barr Virus Protein that is Expressed in Gastric Carcinoma and Inhibits the DNA Damage Response Lori Frappier
4:30 PM β-HPV E6 Inhibits Hippo Pathway Activation Following Failed Cytokinesis Dalton Dacus
4:45 PM Growth Potential and Apoptosis is Inhibited by Localised Topical Microwave Energy in HPV16-positive Cervical Tumour Cells of 3D Organotypic Raft Cultures Michaela Conley
5:00 PM HPV Oncoproteins Promote Expression of Long Noncoding RNA lnc-FANCI-2 via YY1 and miR-29a Haibin Liu
5:15 PM HPV16 E6 and E7 Hypersensitize Head and Neck Tumors to WEE1 Inhibition through Forced Mitotic Entry, Elevated Replication Stress and Defective DNA Damage Response Ahmed Diab
5:30 PM E6 from Oncogenic HPV Strains Recruits USP46 to Stabilize Cdt2 and Promote Cell Proliferation Shashi Kiran
5:45 PM The Relationship Between Pre-cancerous Cervical Lesions, HIV, and the Cervical Microbiome Cameron Klein
6:00 PM Dinner Great Hall
8:00 PM – 10:00 PM Poster Session – Odd Numbered Tripp Commons

 

August 3 Friday  
7:30 AM – 5:00 PM Registration Annex Room
7:30 AM – 8:30 AM Breakfast Lobby
8:30 AM Oral Session III

Part 1: Virus Host Interactions

Session Chairs: Ian Frazer and Sheila Graham

Shannon Hall
8:30 AM The HPV E6 PDZ Binding Motif links DNA Damage Response Signaling to E6 Inhibition of p53 Transcriptional Activity Lawrence Banks
8:45 AM Identification of Differential Gene Expression of a Potential Novel Candidate Tumor Suppressor Gene on Chromosome 11q13 in Non-Tumorigenic and Tumorigenic HeLa x Fibroblast Hybrid Cells Kerstin Maria Lowinski
9:00 AM Furin-Dependent Oligomerization of L2 Shuaizhi Li
9:15 AM Adenovirus Oncogene Product Small E1A Protein Stimulates HBO1 (Myst2) Acetylase Activity Bayar Thimmapaya
9:30 AM The Effect of Productive HPV16 Infection on Global Gene Expression of Cervical Epithelium Sa Do Kang
9:45 AM Therapeutic Target Discovery in Pediatric Recurrent Respiratory Papillomatosis Marion Brusadelli
10:00 AM Cellular Metabolic Changes Associated with ΔE1A Human Adenovirus Infection Martin Prusinkiewicz
10:15 AM

10:30 AM – 11:00 AM

Metabolic Profiling of the HPV16 Infected Epidermis

Refreshment Break

Kanimozhi Vairamani

Lobby

11:00 AM Part 2: Infection/Life Cycle, Immunology Shannon Hall
11:00 AM Viral Attachment and Entry: An Opportunity to Understand and Prevent HPV Infections Jesse Young
11:15 AM Using Novel Inhibitors of BK Polyomavirus to Investigate Viral Entry Mechanisms Joshua Kane
11:30 AM Sneaking Past cGAS/STING: Pathway Regulation by Mitotic Golgi Dispersal Brittany Forte
11:45 AM Host Gene Expression Response to BKV Infection is Cell Type Specific Ping An
12:00 PM Dissecting the Inflammatory Response to Merkel Cell Polyomavirus Infection Nathan Krump
12:15 PM Development of a Virus-Like Particle Vaccine Against BK and JC Polyomaviruses Alberto Peretti
12:30 PM Development of Single-Domain Antibodies Targeting the Human Papillomavirus 16 E6 Protein Guillem Dayer
12:45 PM Dendritic Tropism of Mouse Polyomavirus (MuPyV) Limits Viral Spread and CD8 T Cell Response Qingsong Qin
1:00 PM – 2:30 PM Lunch Buffet Great Hall
2:30 PM Oral Session IV

Part 1: Virus Host Interactions/Replication

Session Chairs: Massimo Tommasino and Cary Moody

Shannon Hall
2:30 PM HDAC Inhibitors Abrogate Productive HPV DNA Amplification in Raft Cultures of Primary Human Keratinocytes (PHKs) Louise Crew
2:45 PM Temporal Recruitment of PML Nuclear Body-Residing Proteins to Incoming HPV Genomes Following Nuclear Delivery Lucile Guion
3:00 PM Regulation of Stromal Type I Interferons by Human Papillomavirus Type 16 Jason Bodily
3:15 PM Regulation of Innate Immune Signaling by Human Papillomavirus 16 E5 Matthew Scott
3:30 PM MCPyV Replicative Stress Induces Senescence in Neonatal Dermal Fibroblasts in a Kap1-Dependent Manner Svenja Siebels
3:45 PM Dual Inhibition of MDM2 and MDM4 in Virus-Positive Merkel Cell Carcinoma Enhances the p53 Response Donglim Esther Park
4:00 PM – 4:30 PM Refreshment Break Lobby
4:30 PM Part 2: Replication Shannon Hall
4:30 PM HPV: The First Virus Known to Use All Three Cellular DNA Replication Polymerases in Its ‘Lytic’ Replication Cycle Thomas Melendy
4:45 PM Murine Polyomavirus Replication Centers Contain Discrete Nanoscale Subdomains Doug Peters
5:00 PM Interaction of the HPV E1 Helicase with UAF1-USP1 Promotes Viral Genome Replication through the Synthesis of Non-Theta DNA Intermediates Marit Orav
5:15 PM Non-Human Primate Papillomaviruses as a Potential Model System for Anti-HPV Drug Testing Eva-Maria Tombak
5:30 PM Replication of HPV Genomes Proceeds Via Distinct Mechanisms Marko Piirsoo
5:45 PM Temporal Dynamics of Adenovirus Gene Expression Leandro Cristomo
6:00 PM NVN1000, a Novel Nitric Oxide Releasing Compound, Reduces HPV-18 E6 and E7 activities and Inhibits viral DNA Amplification and Virus Production in Epithelial Raft Cultures Nilam Sanjib Banerjee
6:15 PM – 8:30 PM Dinner Great Hall
8:30 PM – 10:30 PM Poster Session – Even Numbered Tripp Commons

 

August 4 Saturday  
7:30 AM – 5:00 PM Registration Annex Room
7:30 AM – 8:30 AM Breakfast Lobby
8:30 AM Oral Session V

Part 1: Replication

Session Chairs: Alison McBride and Nicholas Wallace

Shannon Hall
8:30 AM The Anti-Splicing Drug SRPIN340 Inhibits Human Papillomavirus E2 Expression and Viral Replication in Raft Culture Sheila Graham
8:45 AM Viral Transcriptional Enhancer Cis Elements are Necessary for HPV18 Maintenance Replication Tami Coursey
9:00 AM The Role of Protein Kinase CK2 in HPV Replication Marko Piirsoo
9:15 AM Analysis of HPV16 E1-E2 DNA Replication in Oropharyngeal Cancer Cell Lines Molly Bristol
9:30 AM Phosphorylation of Tyrosine 138 in Human Papillomavirus 31 E2 Protein Regulates Brd4 Binding and Viral Genome Replication Leny Jose
9:45 AM Kinase Activity of Fibroblast Growth Factor Receptors Regulate Activity of the Papillomavirus E2 Protein Marsha DeSmet
10:00 AM E6 Mediated STAT3 Activation Occurs Via an NFκB-IL-6-JAK2 Signalling Axis in HPV Positive Cervical Cancer Ethan Morgan
10:15 AM – 10:45 AM Refreshment Break Lobby
10:45 AM Part 2 Transformation Shannon Hall
10:45 AM E6 and E7 from Beta HPV38 and HPV49 Display Different Biological Properties in Transgenic Animal Models Massimo Tommasino
11:00 AM MCPyV T Antigens and their Association with the Fbw7 Ubiquitin Ligase Ann Roman
11:15 AM Prevention of Cervical Cancer by Progestin in the HPV Transgenic Mouse Model Seung Han Baik
11:30 AM Activating Mutations in Pik3ca Contribute to Anal Carcinogenesis in the Presence and Absence of HPV16 Oncogenes Myeoungkyun Shin
11:45 AM Treatment-Naïve HPV+ Head and Neck Cancers Display a T-cell-Inflamed Phenotype Distinct from Their HPV- Counterparts That Has Implications for Immunotherapy Steven Gameiro
12:00 PM Merkel Cell Polyomavirus ST Activates MAPK Signalling to Enhance Tumourigenesis Samuel Dobson
12:15 PM – 2:00 PM Lunch Buffet Great Hall
2:00 PM Oral Session VI

Part 1: Transformation

Session Chairs: Evie Carchman and Ann Roman

Shannon Hall
2:00 PM HPV E4 and E5 Expression in Head and Neck Cancer is Associated with Immune Cell Infiltration James Pipas
2:15 PM Merkel Cell Polyomavirus Large T Antigen Activates the Enhancer of Zeste Homolomogue 2 Expression in Merkel Cell Carcinoma Masahiro Shuda
2:30 PM Role of IQGAP1 in HPV-positive Head and Neck Carcinogenesis Tao Wei
2:45 PM Dysregulation of Cellular Long Noncoding RNAs in Response to HPV Oncogene Expression Surendra Sharma
3:00 PM Role of the Merkel Cell Polyomavirus (MCPyV) Tumor Antigens in Tumor Development Megan Spurgeon
3:15 PM High-Risk Human Papillomaviruses Downregulate Expression of the Ste20 Family Kinase MST1 to Inhibit the Hippo Pathway and Promote Oncogenesis Ethan Morgan
3:30 PM Destabilization of TIP60 by Oncoviruses: From Mechanism to Significance Sudhakar Jha
3:45 PM – 4:00 PM Refreshment Break Lobby
4:00 PM Regulation of Archetype BK Polyomavirus Late Gene and miRNA Expression Wei Zou
4:15 PM Short Half-Life of HPV16 E6 and E7 mRNAs Sensitizes HPV16-Positive Tonsillar Cancer Cells to DNA-Damaging Drugs Kersti Nilsson
4:30 PM Papillomaviruses and Polyomaviruses Associated with Non-Mammalian Hosts Provide Insights into the Evolution of Viral Oncogenes Koenraad Van Doorslaer
4:45 PM Proteomic Pathogen discovery – A Proof-of-Principle Study Using FFPE Tissue and Label-Free Differential Mass Spectrometry Tuna Toptan
5:00 PM Detection of DNA tumor Viruses in Early-Stage Urothelial Carcinoma Gabriel Starrett
5:15 PM Integration of Mouse Papillomavirus Type 1 (MmuPV1) Occurs Often in Benign Tumor Lulu Yu
5:30 PM BK Polyomavirus microRNA Expression and Sequence Variation in Polyomavirus-Associated Nephropathy Hanna Seppälä
5:45 PM Gene Editing Using Cripsr/Cas is Highly Effective in Vivo for HPV-Driven Cancers Nigel Mcmillan
6:30 PM Banquet Dinner Great Hall
8:30 PM Dance Tripp Commons